Development of methods of differential treatment and prevention during the formation of primary placental dysfunction

Abstract

Introduction. The problem of early pregnancy loss remains one of the most urgent in modern obstetrics. According to a number of authors, the frequency of miscarriage in the first trimester of pregnancy is 50%. Such a symptom of the threat of termination of pregnancy as bleeding, when the invasion of the trophoblast occurs and the formation of the placenta begins. Our special attention is drawn to bleeding in the early stages of pregnancy from the so-called "free" zone of the endometrium, which is not occupied by a fertile egg. In the process of implantation and in the early stages of development, the fertile egg occupies only a part and only from 14-16 weeks it fills the entire cavity of the uterus. In the "free" endometrium, decidual transformations characteristic of pregnancy also occur, the hyperplastic endometrium can become necrotized and exfoliate, which leads to the appearance of bloody discharge.