State of indicators of cellular and humoral link of immunity in patients with graves' disease

Abstract

Epidemiological studies conducted in recent years have shown a wide distribution of the thyroid gland diseases. However, the insufficiently studied role of thyroid hormones in the implementation of the functional activity of cells of the immune system determined the relevance of studying the features of the course of inflammation against the background of thyrotoxicosis. The inflammatory process, which continues against the background of these changes, has certain peculiarities of formation and course. These changes are caused by a decrease in the functional activity of cells involved in the formation of an inflammatory response (Ilyinska I.F., 2020). It should be noted that the successful development of fundamental immune-endocrinology has largely clarified the mechanisms and regularities of the interaction of the endocrine and immune systems, and allowed us to determine the place and role of immunological factors in the pathogenesis of endocrine diseases. However, there still are many controversial and unresolved issues. Thus, the question of violations of non-specific and specific immune protection in the development of autoimmune diseases of the thyroid gland remains insufficiently studied today.