FUNCTIONAL KIDNEY STATE OF MATURE RATS WITH RAPID ACETYLATION TYPE UNDER CONDITIONS OF SUBACUTE CADMIUM-NITRATE INTOXICATION AND PREVENTIVE INTRODUCTION OF ECHINACEA PURPUREA

Abstract

Introduction. Functional kidney state under conditions of introduction of Echinacea purpurea tincture before modeling subacute intoxication with cadmium chloride and sodium nitrate was examined in the experiments on laboratory nonlinear albino mature male rats with rapid acetylation type. Purpose. To investigate changes of the kidney functions in mature rats with rapid acetylation type under conditions of subacute cadmium-nitrate intoxication and preventive introduction of Echinacea purpurea. Methods. Male rats 6 months of age with rapid acetylation type were divided into 3 groups: І – control; ІІ – rats with of subacute cadmium-nitrate intoxication model; ІІІ – rats receiving intragastrically alcohol tincture of fresh rhizomes with roots of Echinacea purpurea (LC “State Municipal Enterprise “Pharmaceutical Plant Vishpha””, Ukraine; 0,25 mk/rg). Results. Under the effect of preventive introduction of Echinacea purpurea in rats with rapid acetylation type and cadmium-nitrate lesion of the kidneys diuresis and glomerular filtration rate become normal; distal transport of sodium ions increases; hyponatriemia and decreased natriuresis remain without changes; concentrations of creatinine in the blood plasma, potassium ions in the blood plasma and urine, kaliuresis decrease. Similar to the group of rats without Echinacea purpurea, proximal reabsorption of sodium ions which is standardized by glomerular filtration decreases. Conclusion. Under conditions of preventive introduction of Echinacea purpurea volume regulating kidney function is maintained in mature rats with rapid acetylation type and subacute cadmium-nitrate intoxication, but it does not prevent the development of toxic nephropathy with prevailing lesion of the nephron proximal portion, disorders of ion regulating kidney function and water-electrolytic balance. Keywords: Echinacea purpurea, mature rats, rapid acetylation type, cadmium-nitrate intoxication, kidney functions. Abbreviations: SCNI - subacute cadmium-nitrate intoxication, GFR - glomerular filtration rate.