Роль дисфункції канальців у нирковій волюморегуляції при гіпертонічній хворобі І та II стадії

Abstract

The parameters of the functional activity of renal tubules and regulatory hormones (aldosteron, vasopressin, atrial and digitalis-like natriuretic hormones) were studied in 62 pts with essential hypertension and 21 control subjects prior to and after physiologic hyperhydration. The important differences of the functional rebuilding of the tubules were revealed. The labile phase of essential hypertension was associated with exagerated natriuresis, the stable phase - with detained nathuresis with increased activity of the distal tubules.